Equine IRAP

IRAP (Interleukin receptor antagonist protein) is a treatment for arthritis in horses and humans.

a veterinarian hugging a white horse


Interleukins are compounds in joints largely responsible for the inflammation and pain associated with arthritis. IRAP decreases joint pain by interfering with the activity of Interleukin 1 and similar compounds. For the procedure, you obtain a large syringe of blood. The syringe you pull the blood into has hundreds of glass balls that have been exposed to a certain gas that favors the “IRAP” and helps amplify it. Once the blood is obtained, it is incubated overnight and then spun in a centrifuge to separate the serum from the other components. This serum is rich in IRAP and, once passed through a filter, is injected directly into the desired joint. The extra serum is frozen for subsequent treatments. Typically, a series of 3-4 injections are performed 1-2 weeks apart to treat one affected joint.